RANKL (receptor activator of nuclear factor kappa-B ligand) stimulates osteoclast formation and activity
Outside clinic care brings real risks
Kartal, ., Andres, F., Lai, M
In addition, O 2 reacts with nitric oxide (NO) to generate peroxynitrite (ONOO) (Figure 2), which targets DNA, proteins, and lipids, causing DNA damage, dysfunction of enzymes, receptors, transporters, and membrane channels, as well as protein aggregation, mitochondrial dysfunction, and lipid peroxidation [15]
Future research is expected to expand on this paradigm through the development of triple agonists targeting additional metabolic pathways, exploration of oral and long acting formulations, and refinement of patient selection criteria to maximize clinical benefit while minimizing risk
The goal is to intervene early enough that the referral becomes less urgent or maybe not needed at all