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Around 3 months: Tirzepatide: about 8% Wegovy : about 5% Around 6 months: Tirzepatide: about 15% Wegovy : about 10.5% 1 year and beyond: Tirzepatide: about 21% Wegovy : about 15% These results are from people who reached the highest approved doses used in studies: 15 mg for tirzepatide and 2.4 mg for Wegovy (semaglutide)

Providers should engage in shared decision-making, especially when using medications for off-label indications

Yes, tolerance is often reversible or manageable without discontinuing therapy

LPL, and lipases in general, play crucial roles in providing energy to the body, but it is equally important that they are active only in the correct milieus

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10.1042/cs20180885 Clin