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Together these data indicate that although vagal afferent neurons may contribute to hypophagia induced by peripheral administration of GLP-1R analogs, these neurons are not necessary for the hypophagic effect
Clinical studies show that individuals who stop GLP-1 receptor agonists often regain a portion of the weight they lost within months of stopping treatment
For example, a 72-week study showed 17.8% weight loss with tirzepatide versus 12.4% with semaglutide in adults with obesity but without diabetes
Common side effects may include nausea, diarrhea, and constipation, mainly during the initial phase of treatment
Dosage forms and strengths Tirzepatide is available as a single-use, prefilled syringe in 6 different strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg