Tricyclic antidepressants (TCAs) Amitriptyline and nortriptyline: Effective in managing PDPN by inhibiting monoamine reuptake and blocking sodium channels
Future studies demonstrated that KEAP1 does not passively sequester NRF2 in the cytosol, but actively functions as a ubiquitin ligase, leading to ubiquitination and proteasomal degradation of NRF2 (Zhang and Hannink, 2003)
Finan, B
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In: New York: Oxford University Press
Medicinal herbs: Adverse effects and potential mechanisms of action Along with the increased clinical use of herbal medicines, taken in the form of drugs or food, also attention to their safety, quality, appropriate use and the frequency of harmful or unpleasant adverse reactions (ADR), associated with the use of herbal medicine was increased (Shetti et al., 2011