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Our article on tirzepatide side effects including muscle pain explores potential causes including protein insufficiency during rapid weight loss, electrolyte imbalances, and the effects of significant caloric restriction on muscle tissue

57 , 59 , 60 Scores on the PCS and MCS range from 0 to 100, with higher scores indicating better health status

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Finally, studies published prior to 2018 were included only if they provided foundational pharmacokinetic or pharmacodynamic data on GLP-1 receptor distribution in the CNS or on the initial development of acylated GLP-1 analogs

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