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Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA

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Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress

Additionally, while FOXO4-DRI has been shown to limit chemotoxicity in certain contexts, its overall safety profile in humans requires further research to fully understand all potential side effects

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