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Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRAS(G12C), are associated with renal toxicity in the Sprague Dawley rat

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However, another study using the CLP mouse model found that administering choline before and after sepsis initiation reduced serum inflammatory mediators such as TNF- and HMGB1, and improved survival via the 7nAChR-dependent mechanism (250, 251)

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