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Consequently, the heightened Fe concentration observed in PCOS-induced rats is likely associated with a reduction in the activity of antioxidant enzymes within the PCOS group

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On the other hand GPx3 is negatively correlated with MAPK oncogenic signaling pathway (94), which suggests a potential antitumor effect in thyroid cancer, while a decrease in GPx3 levels predisposes to an increase in the size of primary tumors and the number of metastatic lymph nodes (95, 96)

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Current proposed mechanisms of biguanides include glycolysis simulation in tissues, reducing glucose absorption from GIT with increased glucose to lactate conversion, reduced hepatic and renal gluconeogenesis, in the GI tract and reduction of plasma glucagon levels [123]