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Changes to the retina, such as those that occur from diabetes, can impact its ability to function properly

HbA1c reductions up to 1.6 percentage points Weight trajectory: Weight loss had not plateaued by 52 weeks, indicating potential for further reduction with continued treatment Cardiometabolic: Improvements in waist circumference, blood pressure, hs-CRP, and lipid parameters Evidence level: Moderate -- well-designed phase 2 with NEJM publication, but single trial, no head-to-head comparisons

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In Figure 3, 5 analytes that exhibited 4.5 orders of linear dynamic range (LDR) are shown

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Hypothyroidism, polycystic ovary syndrome (PCOS), and cortisol dysregulation can blunt weight loss despite consistent semaglutide use