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FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci

When that tissue becomes depleted, the upper face can collapse inward, creating a concave, hollowed appearance

An independent fMRI study demonstrated a similar activation of the DLPFC and caudate nucleus during a working memory task in healthy volunteers given amphetamine, a psychostimulant that induces manic-like behaviours [154]

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