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Most common side effects are gastrointestinal: nausea, vomiting, diarrhoea, constipation, and abdominal discomfort

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Many peer-reviewed studies have since followed

Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice

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On semaglutide, people lost about 15% of their body weight over a little more than a year (Wilding, New England Journal of Medicine, 2021), and tirzepatide, what I take, runs higher than that