For 5 mg and above, a more concentrated reconstitution or a larger vial keeps the draw measurable: a 30 mg vial in 2 mL (15 mg/mL) puts 5 mg at about 33 units
NOTE: Dont crush or chew the metformin prolonged release tabled because it can cause a released of whole active drug immediatley which can increase risk of side effect and also therapeutic efficacy and duration of action is decreased
Additionally, UAE studies have indicated its regenerative actions, including the stimulation of blood vessel and nerve outgrowth, synthesis of collagen, elastin, and glycosaminoglycans, support for immune function and nervous system
It has been suggested that it could result from a central action of GLP-1
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