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Novo Nordisk addressed this with a specialised absorption enhancer in oral semaglutide, though the requirement to take the medicine on an empty stomach with no more than 120ml of water, and to wait at least 30 minutes before eating or taking other medications, reflects the ongoing challenge of peptide absorption

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doi:10.1016/j.anl.2004.03.005

doi: 10.1016/j.jclinepi.2016.02.018