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These data represent a qualitative leap forward, as they go beyond the growing body of indirect evidence available so far and demonstrate the potential of GLP-1 receptor agonists as a novel treatment for alcohol use disorder

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Quality of life measures improve as weight decreases, with better physical functioning, reduced joint pain, improved sleep quality, and enhanced psychological well-being

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The distal end (S49 ECD ) of the helix was more mobile than the proximal one (E34 ECD ), which had an overall tendency to remain in the proximity of the TT-OAD2-binding site, driven by transient interactions with the ligand (Extended Data Table 1) and hydrogen bonds with the R299 ECL2 side chain (Extended Data Table 2)

Elevated insulin-like growth factor-1 in Cushings disease