Important safety considerations for transdermal patches: Avoid applying external heat (such as heating pads, hot water bottles, electric blankets, or prolonged sun exposure) to the patch area, as this may increase drug absorption and side effects Do not cut patches or apply additional adhesives unless specifically instructed to do so Wash hands thoroughly after handling patches to avoid transferring medication to eyes or mucous membranes For patients currently using licensed injectable GLP-1 receptor agonists, continue to follow the administration instructions provided in the PIL and by your healthcare team
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Conclusions In conclusion, the obtained results indicated the synovioprotective effect of l-carnitine on KOA via the AMPK-ACC-CPT1 signaling pathway, which is linked to mitochondrial function and lipid accumulation (Fig
