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It is interesting to note that Zn II coordination sites employ ligands from an unstructured region between the first two -helices that for all other MarR regulators is part of a longer 2 helix (Figure 19BC)

The structures of some of the most used peptides are shown below Below is my summary Table for those and a few additional ones that are getting used

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REV-ERB expression is rhythmic, peaking when PER levels are low, and is disrupted in CLOCK, PER1/2 , or CRY1/2 mutant micehighlighting its dependence on the core feedback loop (Preitner et al., 2002)