L-carnitine and trimetazidine are classic cardiovascular protective medicines
These typically include a BMI of 30 kg/m or higher (or 27+ with weight-related comorbidities like hypertension or sleep apnea), combined with documented prediabetes
SELECT Trials Groundbreaking Results In 2023, in a landmark finding, the SELECT trial showed that adults with overweight or obesity but without diabetes, who had previously experienced a heart attack, stroke and/or had peripheral artery disease, taking semaglutide had a 20% reduction in major adverse cardiac events such as heart attacks and strokes compared to those on placebo over the course of 3 years
doi: 10.3934/genet.2017.2.103 21 DisisML
Understanding how these sweeteners affect GLP-1, CCK, PYY, and ghrelin secretion can provide insights into their potential benefits for weight management and metabolic health 2
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