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Common concerns regarding GLP-1 While GLP-1 medications offer hope, they are not without their own set of challenges: Weight regain Some patients experience weight regain once they discontinue GLP-1 therapy, especially if they have yet to make lasting lifestyle changes [6]

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Genetic studies have revealed that IL1B polymorphisms are associated with increased PD risk, suggesting that individual variability in both TNF- and IL-1 may influence disease susceptibility and early onset [184, 189, 195]