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For outcomes with significant findings in some groups, the direction of effects was consistent, although statistical significance was not achieved in all populations

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Strict center assessments are needed before treatment, and the complications caused by these approaches should be noted

Therefore, to further dissociate the effects of GSH and NRF2 on lipid abundance and assess if NRF2 activation alone mimics the effects of liver-specific Gclc deletion, we treated Gclc WT mice with CDDO-methyl (CDDO-Me), a form of bardoxolone with increased bioavailability

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