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When used in combination with lifestyle modifications such as exercise and diet, lipotropic compounds may promote fat and weight loss

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Many experienced users report optimal outcomes in the 0.25mg to 0.5mg range, with diminishing returns above that level

In the anabolic methionine cycle, niacin, in the form of NAD, is a necessary co-factor for the enzymes dihydrofolate reductase in the folate/tetrahydrobiopterin cycle and S-adenosylhomocysteine hydrolase (1)