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256 Besides, extracting small extracellular vesicles from young mice and injecting them into aged mice can significantly prolong the lifespan of the latter

Therefore, it can be applied directly as a topical (graft washing), oral supplement, subcutaneous/intravenous injection, or a combination of multiple routes (similar to the approach applied in our study)

Liposomal formulations are worth considering, since standard oral glutathione is poorly absorbed due to breakdown in the digestive tract

Every needle, every bag, every piece of tubing is sterile and single-use

Retinol works as a cellular exfoliant, accelerating turnover from within

Other potential mtDNA sensing pathways Beyond the well-characterized cGASSTING pathway, accumulating evidence indicates that additional cytosolic DNA sensors may recognize mtDNA and contribute to innate immune activation, although their specific roles within the CNS remain incompletely understood