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Moreover, given the multifactorial pathogenesis of melasma, targeting a single pathological mechanism is unlikely to yield long-term and stable therapeutic outcomes

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Metformin Glipizide Liraglutide Canagliflozin Canagliflozin: An SGLT2 Inhibitor The patients presentation is consistent with diabetic ketoacidosis (DKA) in the absence of hyperglycemia

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Vitamin B6 (Pyridoxine) and B9 (Folate): These take a bit longer, but generally start working within a few hours

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