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The reaction time was 48 h for first and second reactions, 168 h and 216 h for the third and fourth reactions and the fifth reaction, respectively

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These results are consistent with SURPASS2, a 40week, openlabel, phase 3 trial in a cohort of patients with metformintreated T2D in which onceweekly tirzepatide (5, 10, or 15 mg) was noninferior and superior to semaglutide 1 mg for HbA1c reduction and produced substantially greater, dosedependent weight loss