Targeted LC-MS metabolomics analysis revealed enhanced Trp-to-kynurenine flux, elevated lactate, accumulation of citrate/isocitrate/aconitate, and a reduced -ketoglutarate/aconitate ratio (~ 0.6) restored by estradiol (~ 3.6)
Wegovy has shown promising results and can potentially revolutionize the treatment of obesity
Moreover, ovarian aging is associated with an increased risk for diabetes, heart disease, cancer, and other age-related conditions
10.1186/s13578-019-0322-5 16 DrayC.KnaufC.DaviaudD.WagetA.BoucherJ.BulonM.et al (2008)
Side effect log Estimation of medication levels
Nat Commun 14(1):7791 Zhao Z, Chen Q, Qiao X, Wang J, Ali ZTA, Li J et al (2025) Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation