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Medication selection should consider the patient's comorbidity profile, previous medication responses, potential drug interactions, and individual preferences

Most people begin to feel effects within 30 minutes to 2 hours

Oral niacinamide supplements (250-500 mg daily) are safe and well-tolerated for most people

Clinical studies have shown that without adequate protein intake, up to 40% of the weight lost on semaglutide can be lean muscle mass rather than fat

others find weight regain begins within 1-3 months

A narrative synthesis approach was used to summarize findings across studies due to variability in study designs and outcome measures