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After calorie restriction, CTX levels continued to rise in the combination group owing to further weight loss, but these levels decreased during the final phase of the intervention from week 26 to week 52 across all four groups

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Notably, the presence of a single free thiol suggests the potential for undesirable side reactions during tyrosinase-mediated catalysis, such as PfRipr5-Y thiols attacking o -quinones of partner tyrosinase-oxidized PfRipr5-Y, resulting in PfRipr5-Y dimerization