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As for the data it provides from clinical trials, these have been approved by regulatory agencies such as the all-powerful FDA, which is a sign of assurance in terms of their design

Vaquero, A., Sternglanz, R

Real-world data from a Truveta study of over 18,000 patients found that tirzepatide users achieved greater weight loss at 12 months compared to semaglutide users, consistent with the SURMOUNT-5 findings [4]

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The GLP-1 receptor is widely expressed throughout the hypothalamus, with the highest expression in the PVN and ARC (60, 61)