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These pleiotropic effects provide a rationale for exploring their role in multiple organ systems

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Notably, the gut microbiome may impact mood and cognitive function via the gut-brain axis [283,284,285]

Subsequently, PKA activity can augment the release of neurotransmitters into the synapse, facilitating long-term potentiation (LTP) and promoting cAMP-response element binding protein (CREB) phosphorylation, supporting cell growth/survival as well as synaptic plasticity [31, 33]