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A lower K p could indicate a lesser degree of 7,8-DHF accumulation in the brain due to processes like protein binding, lysosomal trapping, and lipid dissolution ( p could also indicate that drug transporters play a role in 7,8-DHF brain distribution

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More complicated molecular modifications that led to the approval of once-weekly products include fusing either recombinant human serum albumin (Tanzeum) or an antibody fragment crystallizable (Fc) moiety (Trulicity) to a GLP-1 analog

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Epub 2011 Aug 18