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When IDO-1 is activated, it negatively impacts cellular energy metabolism by catalyzing the conversion of tryptophan into kynurenine, leading to tryptophan depletion

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Nature 459 , 253256 (2009)

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Antioxidant Gene Expression and Oxidative Stress Pathways The AEDG sequence has also been investigated for its effects on oxidative stress response pathways a research domain that intersects with its pineal and telomere-related activities, since oxidative damage is both a driver of telomere attrition and a consequence of melatonin decline