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The first human trials commenced around 2014, with phase 1 studies evaluating safety, tolerability, and pharmacokinetics in healthy volunteers and patients with type 2 diabetes

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Lower doses of Retatrutide produced more modest but still meaningful weight loss, suggesting that clinicians may have flexibility to tailor treatment intensity based on individual patient needs and tolerability

Khavinson V, Diomede F, Mironova E, et al