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Effect of amifostine in head and neck cancer patients treated with radiotherapy: a systematic review and meta-analysis based on randomized controlled trials

Rosenfeld WN, Davis JM, Parton L, Richter SE, Price A, Flaster E, et al

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However, because long-term human data is limited, ongoing monitoring of IGF-1 levels, glucose, and overall health is strongly recommended

Systemically administered activators do not preferentially enrich in the liver, requiring high systemic exposure to reach therapeutic concentrations in hepatic tissue, increasing the risk of off-target effects and conflicting responses across liver cell types

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