glp 1 vs sglt2 diabetes GLP-1 Receptor Agonists and Inhibitors in Type 2 Diabetes: Pleiotropic Cardiometabolic Effects and Add-on Value of a Combined Therapy | Drugs Kidney and Cardiovascular Effectiveness of

10.1016/j.brainres.2017.10.012 Brain Res

GLP-1 may induce sodium excretion by blocking sodium reabsorption in the proximal tubule through inhibition of sodium-hydrogen exchanger isoform 3 (NHE3) activity [23], as no GLP-1 receptors appear to be present in human kidneys outside of the renal vasculature [19]

Calcium ions play a pivotal role in this process, with cyclic adenosine monophosphate-dependent PKA, CaMKII pathways, and NCXactivated via 1-adrenergic receptor stimulationmediating this mechanism (143)

Keep in mind that fluids are especially important when increasing your fiber intake

I personally use their GLP/GIP + Glycine

GLP-1 (glucagon-like peptide-1) is an endocrinal peptide hormone expressed by the pancreas and by many other organs including the gastrointestinal tract, the heart and the brain 25,26