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Shahid W, Satyjeet F, Kumari R, et al

Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-nave patients with type 2 diabetes (SUSTAIN 4): a randomized, open-label, parallel-group, multicentre, multinational, phase 3a trial

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A phase II trial focusing on individuals with overweight or obesity, coupled with hypertension or dyslipidemia but without T2D, found that cagrilintide (2.4 mg) alongside diet and exercise, led to a 10% body weight reduction compared to 3% with placebo over 26 weeks [99]

So the blunt take is: people can experience mental health changes while on these medicines, but current large scale safety reviews have not confirmed a causal relationship

GLP-1s are not controlled substances, she said