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KAT6A is a member of the MYST family of histone acetyltransferases, which include the closely related KAT6B, as well as KAT5, KAT7, and KAT8 (Voss & Thomas, 2018)

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As just noted, a significant portion of patients is not diagnosed during childhood, as diagnosis of the syndrome can be complex, especially when other psychiatric conditions are also associated

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Under these conditions, mitochondrial dysfunction will compromise metabolic performance in association with increased reactive oxygen species (ROS) generation