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Common adverse effects include nausea and vomiting, as well as increased hazards of gastroparesis and small bowel obstruction

Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)

Amgens statement added that the long half-life, combined with its dual mechanism of action, means the drug may allow for greater durability or reduce the likelihood of weight regain after treatment stops

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Most side effects including digestive symptoms are mild to moderate, often improving after a few days or weeks

Lastly, we included a heterogeneous breast cancer cohort and did not evaluate cancer outcomes, as the primary objective was to assess weight change