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This mechanism can perpetuate the activation and sensitization of meningeal pain receptors through the release of protons, potassium ions, and glutamate

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Children ages 12 and older follow adult dosing guidelines

Most clients begin with weekly injections for a few weeks, then transition to biweekly or monthly injections for maintenance

However, the brain is highly susceptible to oxidative damage due to its high oxygen consumption and limited antioxidant defenses (Sies et al., 2017)

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