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This is uncommon but, if it occurs, may respond to rest, ice, compression, elevation, and over-the-counter anti-inflammatory medications such as ibuprofen or naproxen

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General NSAID Risks (Regardless of Route) Like other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), systemic administration of diclofenac carries serious potential side effects: Gastrointestinal: Increased risk of stomach ulcers, bleeding, or perforation of the intestines