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The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again

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Positive outcomes from these studies could pave the way for formal endorsement by regulatory authorities such as the FDA and EMA

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Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity