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The therapeutic effects of TGR5 agonists could be improved in combinatorial therapy

Discussion The human Fc/J/AIM complex shows the binding of tandem AIM SRCR domains to IgM leading to sequestration and stabilisation of AIM

ZVL is administered as a single dose, but its efficacy decreases with age, showing 70% efficacy in those aged 5059, 64% in those aged 6069, and 38% in those aged 70 and older

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