Opting for smaller portions consumed more often throughout the day can prevent overfilling the stomach
A post-mortem study of human pancreases demonstrated proliferative effects in those cases with GLP-1RA use, which were manifest by an increased mass of the pancreas along with increased frequency of PanIN1 and PanIN2 lesions compared to diabetes controls 23
doi: 10.1586/14737167.2015.1024661 3 KingHAubertREHermanWH
doi: 10.1038/s42255-023-00966-w
This is in contrast with the beneficial effects reported previously for the triagonist, in terms of reversion of adiposity excess and improved metabolic profile in diet-induced obese female mice 42 , suggesting that hyperandrogenism is bound to particular metabolic features that require specific multi-agonist treatments for maximum efficacy
Although this resembles the situation observed under inflammatory conditions, expression of Arx , Pax6 , Isl1 and Lmx1a was increased under inflammatory conditions in intestinal epithelial cells from IL-10 -/- mice ( Figure 2A,B )., arguing against Rfx6 as key driver of skewed differentiation