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Protocol phase 4: maintenance (months 6 through 12 and beyond) Once your tirzepatide dose is stable at maintenance level and your weight loss has begun to plateau, thyroid monitoring can decrease to every 3 to 6 months for the remainder of the first year, then annually if levels remain stable

The dose chart provides a framework, but individualization matters

Some individuals may experience mild, temporary side effects such as: Nausea Gastrointestinal discomfort Reduced appetite (expected effect) These effects often lessen as the body adapts

No additional side effects were identified

Rivellese et al., 2015

2006;291(3):R491-511