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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

Aim to consume roughly 70% of your daily fluids before dinner

Shmerling, MD Senior Faculty Editor, Harvard Health Publishing

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47 Conclusion Management of SCD is complex and multifactorial

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