The key findings were: Tirzepatide met the primary goal of cardiovascular non-inferiority , confirming it is at least as safe for the heart as dulaglutide It did not quite meet statistical superiority over dulaglutide for MACE, although results trended in favour of tirzepatide Tirzepatide produced significantly greater reductions in HbA1c and body weight than dulaglutide Importantly, because SURPASS-CVOT used an active comparator with established cardiovascular benefit rather than a placebo, demonstrating superiority was inherently more difficult than in earlier placebo-controlled GLP-1 outcome trials
Moreover, Ruminococcaceae and Mogibacteriaceae were chosen to be differential gut microbiota biomarkers for walnut oil, which exhibited anti-Alzheimers disease effect against scopolamine-induced mice (64)
[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Koc A, Ozkan T, Karabay AZ, Sunguroglu A, Aktan F
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Hepatic steatosis index (HSI) was calculated using the formula: HSI = 8 (ALAT/ASAT) + BMI + (2 if female) 57 , and fatty liver index (FLI) was defined as FLI = 100 log [0.953 ln(triglycerides) + 0.139 BMI + 0.718 ln(GGT) + 0.053 waist 15.745], where log(x) = 1/1 + e x 58
