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Combining them would negate the primary advantage of the peptide approach

doi: 10.3969/j.issn.1674-2591.2017.02.008 73

While the active drug substance is carefully optimized to minimize immune responses, peptide-related impurities may significantly alter immunogenic potential, even when present at low levels

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How many people are using GLP-1 medications By 2022, semaglutide become the dominant GLP-1 medication, accounting for 54% of use among adults with diabetes and 65% among adults without diabetes, the study noted