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Nonrandomized real-world evidence to support regulatory decision making: process for a randomized trial replication project

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During acclimatization, mice had ad libitum access to standard chow (SD) in a food hopper, and to water bottles, running wheels, shelters and bedding

Evidence Synthesis Given heterogeneity in models, dosing, and outcome reporting, findings were summarized using structured narrative synthesis rather than quantitative pooling