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Here, we characterise the in vitro and in vivo effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice

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Platelet aggregation studies also revealed hyperreactivity to ADP of WT platelets suspended in plasma taken from GPx-3 (/) mice compared with GPx-3 (+/+) mice, which recapitulated the findings in the original human study

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Such hyperandrogenemia has a deleterious impact on ovulation and metabolic function, promoting adiposity and insulin resistance 5