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The Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness (GRADE) study [16] found that GLP-1 RA (i.e., liraglutide) was significantly more effective in achieving and maintaining target levels of HbA1c compared with sulfonylureas (i.e., glimepiride) and DPP4i (i.e., sitagliptin) after an average follow-up of 5 years among those with T2D who were on metformin

"All of weight loss involves not just losing fat but also losing muscle," he said

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This can lead to a build-up of visceral fat the particularly harmful type that wraps around your internal organs