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"Glucagon-like peptide-1 receptor modulates cerebrospinal fluid secretion and intracranial pressure in rats." Fluids Barriers CNS

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Nella letteratura scientifica, la principale differenza strutturale il numero di recettori attivati: Retatrutide (LY-3437943) un triagonista che attiva GLP-1R, GIPR e GCGR, mentre Tirzepatide (LY-3298176) un doppio agonista che attiva GLP-1R e GIPR