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Participants were randomly assigned, 1:1:1, to once-weekly combination cagrilintide and semaglutide 2.4 mg, once-weekly semaglutide 2.4 mg plus placebo or once-weekly cagrilintide 2.4 mg plus placebo

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Marzieh SH, Jafari H, Shorofi SA, Setareh J, Moosazadeh M, Espahbodi F, et al

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Semaglutide acts on the GLP-1 pathway alone, while Tirzepatide activates both the GLP-1 and GIP pathways for a combined effect on appetite control, fullness, and metabolic support